Writer: Dr. Ruiyang Ge @ University of British Columbia The ENIGMA Lifespan Working Group is excited to share their latest work in estimating the biological age of the brain using structural neuroimaging data: "Brain-age prediction: Systematic evaluation of site effects, and sample age range and size". This method, known as brain-age estimation, has proven to be a valuable tool in understanding brain development and aging, offering insights into various biologically and behaviorally...

Writer: Dr. Ruiyang Ge @ University of British Columbia 22q11.2 deletion syndrome (22q11DS) stands as the most prevalent microdeletion in humans. This genetic condition is linked to notable effects on brain structure, marked by substantial reductions in gray matter volume. Additionally, it manifests in neuropsychiatric symptoms, encompassing cognitive impairment and psychosis. The ENIGMA 22q11.2 Deletion Syndrome Working Group has recently shared a publication entitled "Source-based...

Writer: Dr. Shalaila Haas @ ISMMS This study was the first application of the robust and large scale normative models developed by Ge and colleagues to a clinical sample. Normative modeling provides standards or "norms" at different ages for specific measures. In this case, normative models were generated for each region in the brain in more than 37,000 healthy individuals. These models can then be applied to other datasets, for example patients with a specific mental illness, to determine...